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- ArticleFravolini A, Schiaffella F, Strappaghetti G, Volpato I, de Regis M.Farmaco Sci. 1978 Nov;33(11):855-65.A series of carboxamides of benzotiopyranopyrazoles and benzothiiopyranoisoxazoles was synthesized starting from benzothiopyran-4-one-3-methylglyoxylates through two synthetic methods and tested for anti-inflammatory, analgesic and cardiovascular activity. Some of these compounds display pronounced antiarrhythmic activity.